Love Island USA‘s Jeremiah Brown made a guest cameo on St. Denis Medical — just in time for a romance story line.
During the Monday, November 24, episode of the NBC sitcom, Matt (Mekki Leeper) and Serena (Kahyun Kim) are treating a patient who keeps fainting without an explanation. The nurses try to help him figure out what is causing him to pass out, which they are only able to solve once Brown’s character appears.
It turned out that the patient had a crush on his roommate — played by the reality star — but he didn’t realize it until it turned into a medical issue. Matt and Serena remained hopeful about the outcome of their patient’s love life while dealing with their own secret feelings for each other.
St. Denis Medical follows overworked doctors and nurses trying their best to care for patients at an underfunded Oregon hospital. In addition to Leeper, 31, and Kim, 36, the mockumentary stars Wendi McLendon-Covey, David Alan Grier, Allison Tolman, Josh Lawson and Kaliko Kauahi.
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When the series premiered on NBC in 2024, viewers couldn’t help but notice that Matt and Serena’s romance could make them the next fan-favorite sitcom couple. Creator Eric Ledgin didn’t rule out a potential romance between Matt and Serena.
“There’s definitely at least a one-sided will-they-or-won’t-they happening,” he teased to Us Weekly at the time. “So I can tell you it’ll definitely be a slow burn of something that we will track over time.”

During the season 2 premiere earlier this month, a brief time jump revealed that Matt and Serena were working in different parts of the hospital. Serena requested the change to help Matt get over his feelings for her — until she realized Matt asked for the same thing.
Matt then told Serena he was able to move on from her, which hinted that now Serena was more aware of her feelings for Matt than the other way around.
“Like a real relationship, you got to get to know each other,” Leeper exclusively told Us this month. “There’s some stop and start there.”
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Leeper teased Matt’s state of mind. “He doesn’t want to be too desperate and wants to kind of play it cool. Sometimes that means you have to step back for a season,” he explained. “I like that they’re not a classic sitcom-like romance.”
He continued: “They’re both really weird in their own right. If they weren’t dating, it would be just two interesting characters. I think it’s cool that we get to be weirdos together.”
Kim, meanwhile, hinted that there would be more surprises as the season plays out.
“A lot of things happen in season 2,” she added. “A lot of ups and downs so it definitely continues to grow and mold into something. It’s very exciting.”
St. Denis Medical airs on NBC Mondays at 8 p.m. ET before streaming the next day on Peacock.

